Register to the 2015 ELA Families / Scientists Meeting

Written on Thursday 22 January 2015

Each year, the ELA association organizes a meeting for patients and their families. International scientists will attend the meeting where they will present the latest scientific and medical breakthroughs and answer the questions of patients and families. This annual event is a unique opportunity for the patients and their families to gain knowledge and interact […]

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Launch of the MD1003 trial in adrenomyeloneuropathy in France and Spain


Written on Monday 24 November 2014

We are happy to announce the launch in France and Spain of the clinical trial testing the MD1003 drug developed by MedDay Pharmaceuticals in patients with adrenomyeloneuropathy (AMN). Authorizations for the investigational center in Germany are awaited. The trial, funded by ELA for 800.000 euros, will gather 60 AMN men with no cerebral involvement. Below […]

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Characteristics of Krabbe disease in adults


Written on Monday 24 November 2014

Krabbe disease is a leukodystrophy where the severe form usually begins in early infancy, during the first year of life, and progresses rapidly. It causes demyelination of the central and peripheral nervous systems. The aim of this study was to describe the clinical, radiological and genetic characteristics of Krabbe disease in adult patients for whom […]

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Study of cerebral metabolic impairment in metachromatic leukodystrophy


Written on Tuesday 21 October 2014

Metachromatic leukodystrophy (MLD) is a neurodegenerative metabolic disease caused by a deficiency in a protein named arylsulfatase A.  The defect leads to the accumulation of sulfatides in the nervous system. The aim of this study was to measure brain metabolic impairment in 4 children suffering from the late infantile form of the disease, with the […]

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A derivative of vitamin E aids in the repair of myelin in multiple sclerosis


Written on Wednesday 15 October 2014

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) that causes demyelination and axonal loss, resulting in a severe neurological handicap. Current treatments of MS are mainly aimed towards neuro-inflammation and have a minor impact on myelin repair in the CNS. A treatment that stimulates remyelination would represent a major advance […]

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Mesenchymal stromal cell transplant induces re-myelination in a multiple sclerosis model


Written on Monday 29 September 2014

Demyelinating diseases such as leukodystrophies and multiple sclerosis are neurodegenerative diseases characterized by a progressive loss of myelin and cells responsible for its synthesis, the oligodendrocytes. Upon demyelination, the cells giving rise to oligodendrocytes are activated and can migrate towards the injured zone where they change into oligodendrocytes. Unfortunately, when demyelination becomes chronic, the cells […]

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Disruption of neovascularization in Krabbe disease


Written on Tuesday 23 September 2014

Krabbe disease, also known as globoid cell leukodystrophy, is a neurologic illness caused by the lack of a protein called β-galactosylceramidase, which leads to the abnormal accumulation of a toxic component, psychosine, in the central nervous system (brain and spinal cord). This disease is characterized by an alteration in the cells that synthesize myelin, known […]

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